3,3'-diindolylmethane is abbreviated to DIM to keep it simple. This remarkable phytonutrient is naturally found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage, kale and cauliflower.
As a health supplement DIM can assist better hormone balance in both women and men. More specifically... it can aid healthy estrogen breakdown and elimination.
A ground breaking DIM ingredient has been developed by researchers at BioResponse® Nutrients, USA. In Australia, the trade name Indolplex® is used. In the USA look for products containing BioResponse®-DIM. These products contain pure, micro-encapsulated DIM with enhanced bioavailability.
Estrogens are the main female hormones, although they are also found in smaller quantities in men with levels increasing with ageing. Estrogens have a powerful effect on health.
Estrogens is the collective term for estradiol (E2), estrone (E1) and estriol (E3). A higher activity of estrogens, often referred to as ‘estrogen dominance’ is an increasingly serious problem for both women and men.
Estrogen activity can be raised by external influences, such as use of the oral contraceptive pill, hormone replacement therapy (HRT), fertility drugs, obesity, stress and estrogen mimicking environmental chemicals.
The way estrogens are cleared from your body is critical to reducing estrogen dominance. Estrogens are modified and eliminated down three major clearance pathways. This leads to the formation of break down compounds with dramatically different biological activities.
An over load of estrogens in the form of highly active metabolites is responsible for a vast number of today's hormone health conditions.
In women, unhealthy estrogen metabolites can be responsible for many unfavourable effects, including weight gain, breast disorders and reproductive health issues. In men, these estrogen metabolites contribute to weight gain and prostate problems.
Emerging evidence demonstrates that Indolplex® may be beneficial in detoxifying estrogens down the protective pathway. The healthy estrogen compounds that are formed are termed ‘good’ estrogen metabolites.
These metabolites help safeguard the body from the negative effects of too much estrogen. When Indolplex® increases the desirable estrogen metabolites there is a simultaneous reduction in the levels of unhealthy, or so called ‘bad’ estrogen metabolites.
In summary, Indolplex® assists effective estrogen metabolism towards the production of protective estrogen metabolites along with a simultaneous reduction in the levels of undesirable forms to assist hormone health.
Ongoing scientific research supports the proposal that favourable clearance of estrogens is fundamental to maintaining breast, uterine, cervical and prostate health.
Indolplex® is not considered a plant estrogen. That is, it does not exert a phytoestrogenic effect. Nor does Indolplex® increase estrogen clearance. Rather, it can help modify estrogen activity and detoxification down the safer metabolic pathway.
Supplemental use of Indolplex® allows both men and women to promote healthy metabolism of estrogens and the formation of oestrogen metabolites that can help reduce estrogen dominance.
Indolplex® is indicated in a wide range of hormonal and reproductive disorders affecting women. It is used to treat pre-menstrual syndrome (PMS), fibrocystic breast disease, polycystic ovarian syndrome (PCOS), uterine fibroids, cyclical mastalgia and cervical dysplasia. For men, Indolplex® can assist prostate problems and weight loss.
Some supplements contain indole-3-carbinol (I3C), a precursor to DIM. However, I3C is unstable and reacts in the stomach converting to DIM and unfavourable non-DIM compounds. This means I3C must be taken at much higher amounts and can undergo unpredictable chemical reactions. This makes DIM by far the preferred supplement.
Look for pure, bioavailable DIM featured in the Indolplex® product range. This micro-encapsulated DIM complex ensures safety and effectiveness when taken as recommended. Ongoing research now focuses on bioavailable DIM, not I3C to naturally assist hormone health.
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