Physical and emotional stress takes a serious toll on thyroid health. Ongoing stress triggers greater production of cortisol, the body's main stress hormone. Elevated cortisol inhibits conversion of thyroxine (T4) to active triiodothyronine (T3). The consequence is T4 then converts to reverse T3, an inactive form of T3.
Reverse T3 dominance may persist even when your stress levels settle down and cortisol levels return to normal. This is because the reverse T3 continues to inhibit the conversion of T4 to T3, perpetuating production of the inactive T3 hormone.
T3 is the most potent thyroid hormone and every cell in the body has molecular docking station for this hormone. If however you have the condition known as reverse T3 dominance T4 is no longer converting to T3. Instead T4 is being converted to inactive 'reverse T3'.
Reverse T3 has the same molecular structure as T3 however it is a mirror image of T3 and therefore fits into the receptor upside down. This prevents the active T3 from binding to the receptor site and activating the appropriate thyroid response.
Reverse T3 slows metabolism, causing weight gain. It also causes the typical signs and symptoms of hypothyroidism.
Reverse T3 Warning
Diagnosing Low Thyroid Function
Reverse T3 Dominance Testing
Reverse T3 Dominance Treatment
Thyroid Gland Function
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